Antibody Engineering (Scientist) 시작일: 협의 가능 장소 : 대전
일반 요약 오름테라퓨틱은 ADC(항체-약물 접합체)와 TPD(표적 단백질 분해)의 장점을 융합한 플랫폼을 기반으로 하는 항암제 중심의 글로벌 바이오텍 회사입니다. 당사는 페이로드가 한정적인 ADC의 한계 및 세포에 대한 선택성이 부족한 TPD의 한계를 극복한 TPD² (Dual-Precision Targeted Protein Degradation, 이중 정밀 표적 단백질 분해 접근법) 기술을 개발하여 기존 치료제의 혜택을 받지 못하는 환자를 위한 혁신 신약을 개발하고 있습니다. 당사는 모든 구성원들이 수평적인 구조 내에서 유기적인 협업 및 자기 주도적 업무수행을 장려하는 기업 문화를 바탕으로 대전 본사와 미국 보스턴에 연구소를 운영하고 있습니다. 현재 대전 연구소에서는 항체 기술에 기반한 신약 개발을 함께 하실 인재를 채용하고자 하오니 많은 관심과 지원 바랍니다.
General Summary Orum Therapeutics is seeking a highly motivated scientist to contribute to our efforts for the discovery and development of antibody-based therapeutics. The successful candidate(s) will have a strong background in molecular biology and a passion for driving high-impact projects in innovative anti-cancer drug discovery space. The candidate will conduct bench-based research focused on molecular work for antibody engineering, antibody production, analytical characterization/quantitation for ADC, m Abs, and data analysis and report within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.
Principle Duties and Responsibilities
Support the generation of novel antibodies using display and hybridoma technology
Apply molecular modeling technology to analyze antigen-antibody complex structures, and design/modify antibody CDRs to improve the function of antibodies by computationally designed rational libraries and random focused libraries
Analyze biochemical and biophysical characteristics of antibodies and antibody drug conjugates
Antibody production using transient expression system
Learn and implement new scientific findings and technologies to antibody discovery
Contribute to developing Orum’s novel antibody-based platform technology
Actively communicate and discuss study design and results with the team
Skills, Abilities & Competencies
Experience in molecular biology to support the various engineering techniques
Experience with protein binding assays (Octet, Biacore, ELISA etc.) and protein analytics.
Expertise protein purification by standard chromatography methods (Affinity, ion exchange, hydrophobic interaction, SEC) as well as fluency with the theoretical concepts underlying protein purification
Highly motivated and capable of working independently as well as part of a team
Excellent documentation and communication skills, with proficiency in English preferred
Ph.D. or Masters in biochemistry, molecular biology, protein/antibody engineering, or related field with extensive laboratory experience
Work experience in the biotech/pharmaceutical industry preferred but not mandatory